Figure 7 | Scientific Reports

Figure 7

From: Cyperenoic acid suppresses osteoclast differentiation and delays bone loss in a senile osteoporosis mouse model by inhibiting non-canonical NF-κB pathway

Figure 7

Effect of cyperenoic acid on bone histomorphometry at distal femur in SAMP6 mice. SAMP6 mice were fed with the standard diet food AIN-93M (A) or the standard diet food supplemented with 0.01% cyperenoic acid (B) for 19 weeks. Representative microscopic image of femoral bone at distal end stained with safranin O (orange), fast green (green) and hematoxylin (blue) are shown. Bone histomorphometric parameters of bone volume normalized by tissue volume (BV/TV) (C), trabecular thickness (Tb.Th) (D), trabecular separation (Tb.Sp) (E) and trabecular number (Tb.N) (F) were calculated. The analyzed areas covered the trabecular region at 500 µm distal to the growth plate. Each dot represented each animal. Scale bar = 200 μm, *p < 0.05 indicated statistical significance. Trabecular bone (TB), Cortical bone (CB).

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