Figure 4
EBOV miRNA distributions are similar in different disease models. The relative abundance of each EBOV miRNA species detected was plotted as a percentage of the total EBOV miRNA content per day in the (a) BALB/c mouse model infected with mouse-adapted EBOV/Mayinga, (b) rhesus macaque model infected with EBOV/Kikwit, (c) cynomolgus macaque model infected with EBOV/Makona, and (d) human samples from the EBOV/Makona outbreak in 2014. In the animal models, samples were grouped by day post-exposure, whereas human samples are shown individually and arranged by day post-symptom onset. The aggregated miRNA distributions for each model are given in the last bar for each graph. EBOV viral loads (mean ± SD of biological replicates, where applicable, assayed in technical triplicate) are shown for comparative purposes, and filled circles represent a positive PCR result for the viral glycoprotein sequence.
