Table 3 EBOV miRNAs were detected in BALB/c mice intraperitoneally injected with mouse-adapted EBOV/Mayinga.

From: Virus-encoded miRNAs in Ebola virus disease

EBOV miRNA

miRNA concentration by day post-exposure (fM)

Day 0 (EBOV load ND)

Day 1 (4.17E-05 pM)

Day 2 (0.04 pM)

Day 3 (3.99 pM)

Day 4 (20.20 pM)

Day 7 (0.22 pM)

miR-1-3p

ND

ND

ND

8.82 ± 6.92

20.94 ± 14.68

51.32 ± 37.27

miR-1-5p

ND

ND

1.08 ± 0.99

8.52 ± 1.51

25.11 ± 2.55

129.37 ± 6.68

miR-2-3p

ND

ND

ND

2.40 ± 1.23

5.00 ± 1.11

12.41 ± 2.36

miR-T1-3p

ND

ND

ND

0.74 ± 0.16

1.78 ± 0.41

18.44 ± 1.83

miR-T1-5p

ND

ND

ND

ND

14.57 ± 8.14*

ND

miR-T2-3p

ND

ND

ND

ND

2.49 ± 0.77

1.26 ± 0.92

miR-T3-3p

ND

ND

0.83 ± 0.82

3.45 ± 2.86

12.46 ± 6.77

101.75 ± 10.34

miR-T3/T4-5p

ND

ND

0.07 ± 0.12

2.32 ± 0.76

3.74 ± 0.92

46.81 ± 3.31

miR-T4-3p

ND

ND

1.19 ± 2.06

3.67 ± 1.16

6.25 ± 3.87

55.58 ± 7.26

miR-VP-3p

ND

ND

ND

0.05 ± 0.10

0.30 ± 0.46

0.62 ± 1.07

  1. Note: Data are presented as the mean ± SD of biological replicates assayed in technical triplicate. Values in bold font indicate amplification in only one of three biological samples, with mean ± SD only for that sample. The corresponding EBOV load at each timepoint is given in parentheses below each day. ND = not detected. *Value given is based on the mismatched miR-T1-5p sequence.
Back to article page