Figure 1 | Scientific Reports

Figure 1

From: Low-dose tributyltin exposure induces an oxidative stress-triggered JNK-related pancreatic β-cell apoptosis and a reversible hypoinsulinemic hyperglycemia in mice

Figure 1

TBT decreased cell viability and induced apoptosis in β-cells. RIN-m5F cells were treated with or without TBT (0.1–1 μM) for 1–24 h. (A) Cell viability was determined by MTT assay in a dose-dependent manner (a) and a time-dependent manner (b). (B) Apoptotic or necrotic cells were determined by flow cytometry analysis with acridine orange/ethidium bromide fluorescent probes. Data are presented as mean ± SEM of four independent experiments with triplicate determinations in each experiment. *P < 0.05 as compared to vehicle control.

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