Table 2 Differential metabolites in plasma between SYDS patients and healthy volunteers.
From: Integrative metabolic and microbial profiling on patients with Spleen-yang-deficiency syndrome
RT/min | Exact mass | Metabolites | Formula | Fold change SYDS/Health | Related pathway |
|---|---|---|---|---|---|
7.79 | 284.295 | Sphinganine | C18H39NO2 | −4.9** | Sphingolipid metabolism |
2.46 | 766.6589 | Galactosylceramide(d18:1/22:0) | C46H89NO8 | 9.4** | Sphingolipid metabolism |
5.46 | 379.2484 | Sphingosine 1-phosphate | C18H38NO5P | −2.0** | Sphingolipid metabolism |
5.64 | 380.2574 | Dihydrosphingosine 1-phosphate | C18H40NO5P | −2.0** | Sphingolipid metabolism |
1.17 | 133.0141 | L-malic acid | C4H6O5 | −2.4** | TCA cycle |
1.74 | 117.0191 | Succinic acid | C4H6O4 | −3.8** | TCA cycle |
1.75 | 261.0582 | Citric acid | C5H6O4 | 5.9** | TCA cycle |
1.12 | 349.0888 | N-acetyl-L-aspartic acid | C6H9NO5 | −1999.7** | Alanine, aspartate and glutamate metabolism |
1.35 | 307.0346 | dUMP | C9H13N2O8P | −2.7** | Pyrimidine metabolism |
3.18 | 240.9765 | 3-mercaptopyruvic acid | C3H4O3S | −619.1** | Cysteine and methionine metabolism |
1.43 | 263.1242 | 4-hydroxyproline | C5H9NO3 | −∞** | Arginine and proline metabolism |
1.12 | 387.1513 | 2-methylhippuric acid | C10H11NO3 | +∞** | Fatty acid beta-oxidation |
2.16 | 217.0287 | Hypotaurine | C2H7NO2S | 55.3** | Taurine and hypotaurine Metabolism |
5.14 | 585.2700 | Bilirubin | C33H36N4O6 | −3.1** | Porphyrin and chlorophyll metabolism |
1.06 | 181.0712 | Sorbitol | C6H14O6 | −2553.2** | Fructose and mannose metabolism |
1.09 | 321.0946 | 4,6-dihydroxyquinoline | C9H7NO2 | −5.6** | Tryptophan metabolism |
1.35 | 89.0244 | L-lactic acid | C3H6O3 | 1.8** | Glycolysis/Gluconeogenesis |
5.46 | 317.2465 | Tetrahydrodeoxycorticosterone | C21H34O3 | −7.5* | Steroid hormone biosynthesis |
