Figure 3 | Scientific Reports

Figure 3

From: The C-terminal HRET sequence of Kv1.3 regulates gating rather than targeting of Kv1.3 to the plasma membrane

Figure 3

TEA inhibition of full length and C-terminal removed H399K channel. (A) Whole-cell currents of EGFP- and FLAG-tagged H399K-FL channels in CHO cells were recorded during 200-ms-long pulses to 0 mV (not to + 50 mV to reduce whole-cell current) from a holding potential of −120 mV. Traces are shown before (black) and after addition of 100 mM TEA (purple). (B) Currents of the EGFP- and FLAG-tagged H399K-ΔC construct in the presence (purple) and absence (black) of 100 mM TEA. The same voltage-clamp protocol was used as on panel A was used to evoke the currents.

Back to article page