Figure 9
From: Etidronate prevents dystrophic cardiac calcification by inhibiting macrophage aggregation
Effect of PPi and etidronate on DCC in Abcc6−/− and C3H mice. Calcification was induced in DCC-susceptible Abcc6−/− mice (A) and C3H mice (B,C) by freeze–thaw injury. Mice were treated with PPi (1 day before injury, then daily for 1 week) (A,B) or etidronate (Etd) (at the indicated time points) (C). Control mice were injected with NaCl or PBS. One week after injury, hearts were collected. Whole heart (Panel A and C) or Healthy myocardium and necrotic myocardium (Panel B) from the same heart were excised, and calcium phosphate deposits were assessed. PPi- and etidronate-treated mice were compared with PBS- or NaCl-treated (control) mice.
