Table 1 Release constants k and time offsets t0 for the different samples at different temperatures as determined from non-linear regression of the experimental release data with the model presented in Eq. 5.

From: Controlling Indomethacin Release through Vapor-Phase Deposited Hydrogel Films by Adjusting the Cross-linker Density

 

T [°C]

t0 [min]

k [10−3 min−1]

R²

No coating

amorphous (as-prepared)

25

0.39 ± 0.17

320 ± 5

0.978

amorphous (heated)

25

156 ± 5

0.985

crystalline

25

1.35 ± 0.14

38.9 ± 0.9

0.998

25% EGDMA

25

20.2 ± 1.4

2.0 ± 0.1

0.995

37

5.75 ± 0.16

5.58 ± 0.04

0.988

50

3.1 ± 0.5

21.5 ± 0.8

0.995

50% EGDMA

25

0.196 ± 0.002

0.995

37

1.4 ± 0.4

0.388 ± 0.006

0.995

50

1.19 ± 0.04

0.982

100% EGDMA

25

0.030 ± 0.004

0.775

37

0.180 ± 0.005

0.986

50

6.2 ± 1.7

3.0 ± 0.2

0.932

  1. The parameter uncertainty is given as the (fit) standard error, is the coefficient of determination of the fit.