Figure 7
From: Cyclin-dependent kinase 5 mediates pleiotrophin-induced endothelial cell migration
Schematic representation of the proposed PTN pro-migratory signaling pathway that leads to CDK5 activation in human endothelial cells. PTN induces RPTPβ/ζ stimulation that triggers an RPTPβ/ζ-p35-CDK5 interaction. This event leads to CDK5 activation and is independent of the PTN-induced migratory signals through integrin ανβ3. Furthermore, RPTPβ/ζ stimulation may lead to CDK5 activation through a PI3K-dependent manner. Finally, we show that Rac1 lies downstream of CDK5 and is necessary for PTN-induced endothelial cell migration.
