Figure 5
From: Mitochondrial function in individuals at clinical high risk for psychosis
Association between peripheral mitochondrial complex IV function and [18F]FEPPA total distribution volume (VT) of hippocampus in clinical high risk (CHR) (r = −0.42, p = 0.04), but not in healthy controls (HC) (r = 0.07, p = 0.82). Mitochondrial complex (I–V) function was measured in monocyte samples (white blood cells) in a multiplex ELISA assay. Complex function is reported as a percentage against each subject’s individual nicotinamide nucleotide transhydrogenase levels (%NNT); a nucleus-encoded protein present in the inner mitochondrial membrane that is closely related to mitochondrial oxidative phosphorylation. [18F]FEPPA VT was determined with a 2-tissue compartment model using positron emission tomography (PET). Partial correlations were used to explore the associations between mitochondrial complex function and [18F]FEPPA VT, controlling for translocator protein 18 kDa (TSPO) rs6971 polymorphism.
