Figure 5
From: IgG-single-chain TRAIL fusion proteins for tumour therapy
In vivo anti-tumour activity of HC-scTRAIL. (a) PBS or 0.3 nmol of either HC-scTRAIL or Fc-scTRAIL-FAVSGAA were administered i.v. to Colo205 bearing nu/nu mice twice a week for a total of six doses, starting from day 14. Administrations are indicated by dotted lines. At day 39, 100 µg Smac mimetic SM83 was administered i.p. as a co-treatment, together with a total of 4 i.v. doses of PBS or 0.3 nmol of the scTRAIL fusion proteins twice a week (n = 12 tumours, mean ± 95% C.I.). (b) Individual tumour volumes at day 35 (mean ± 95% C.I.).
