Figure 2 | Scientific Reports

Figure 2

From: Integrative annotation and knowledge discovery of kinase post-translational modifications and cancer-associated mutations through federated protein ontologies and resources

Figure 2

NIH metric versus annotation score. Scatter plots of annotation score ω versus the three measurements (in log scale) used in the NIH metric: (a) Jensen score, (b) R01 count, and (c) PubTator score, respectively. Spearman’s rank correlation coefficient ρ is shown in each scatter plot. (d) Visualization of the three annotation categories in the human kinome tree. BS/Low: better-studied protein kinases with low ω (red nodes); US/High: under-studied protein kinases with high ω (green nodes); US/Low: under-studied protein kinases with low ω (blue nodes); all the unmarked protein kinases are better-studied protein kinases with high ω, such as EGFR. Node size scales with the ω score. The five proteins with the highest ω in US/High category are labelled; the five proteins with the lowest ω in BS/Low and US/Low categories, respectively, are also labelled. The human kinome tree was generated using KinMap43. Illustration is reproduced courtesy of Cell Signaling Technology, Inc. (http://www.cellsignal.comwww.cellsignal.com).

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