Figure 3

Annotation scores of protein kinases with enriched domains and visualization of the enriched domains in the human kinome tree. (a) Data volume, variety, and annotation score ω for each protein kinase with enriched VEA and MEA. The name of the protein kinase is shown in the first column in red if it is better-studied or green if under-studied; gradient colour (red for the maximum and blue for the minimum in the whole human kinome) indicates the data volume for each variable (column 2–16) and ω (last column). A threshold of high ω ( >1.00) is shown by a red line. (b) Protein kinases with functional domains with adjusted p-values in VEA or MEA less than 0.005 are represented by red and blue nodes, respectively; node size represents the score in VEA or MEA. Protein names are labelled only if any of their functional domains shows significant adjusted p-values in both VEA and MEA; black labels represent proteins with enriched protein kinase domains (either Pkinase or Pkinase_Tyr), while gray labels show proteins that only have other enriched domains; enriched domains are shown in parentheses. The human kinome tree was generated using KinMap⁴³. Illustration is reproduced courtesy of Cell Signaling Technology, Inc. (http://www.cellsignal.comwww.cellsignal.com).