Figure 6 | Scientific Reports

Figure 6

From: Integrative annotation and knowledge discovery of kinase post-translational modifications and cancer-associated mutations through federated protein ontologies and resources

Figure 6

Mutation and PTM sites in the C terminal tail domain of AGC kinases. (a) Mutation and PTM sites in enriched protein kinase C terminal tail domains. X-axis: sequence position and corresponding PKA position/subdomain/motif; y-axis: mutation frequency across all cancer samples in COSMIC; red dot: phosphorylation; yellow dot: methylation; dot on top of the bar: mutation-PTM overlapping site; AST: active-site tether subdomain; NLT: N-lobe tether subdomain; NFD: NFD motif; T: turn motif; HF: hydrophobic motif. (b) Mutation and phosphorylation sites in all protein kinase C terminal domains. Sequences of all protein kinase C terminal tail domains defined by Pfam are aligned to PKA sequence by MAFFT alignment; black rectangles: subdomains; red rectangles: motifs; residues marked in blue: mutation sites (frequency is ignored); residues marked in red: phosphorylation sites; residues marked in purple: mutation-phosphorylation overlapping sites.

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