Table 1 Domains enriched in both disease variants and PTMs. Adj-PV: adjusted p-value; Average score: an average of VEA score and MEA score; bold text: protein kinase domains (either Pkinase or Pkinase_Tyr).
Gene Symbol | UniProtKB ID | Domain | VEA Adj-PV | MEA Adj-PV | Average Score |
|---|---|---|---|---|---|
EGFR | P00533 | Pkinase_Tyr | <1.00E-14 | <1.00E-14 | 14.000 |
ERBB2 | P04626 | Pkinase_Tyr | 4.32E-14 | 6.70E-06 | 9.269 |
BRAF | P15056 | Pkinase_Tyr | <1.00E-14 | 3.42E-05 | 9.233 |
MAP2K3 | P46734 | Pkinase | <1.00E-14 | 5.33E-05 | 9.137 |
PRKCB | P05771 | Pkinase | <1.00E-14 | 3.68E-04 | 8.717 |
CHEK2 | O96017 | Pkinase | <1.00E-14 | 6.68E-04 | 8.588 |
EPHA5 | P54756 | Pkinase_Tyr | 7.55E-14 | 2.22E-03 | 7.888 |
FLT3 | P36888 | Pkinase_Tyr | 1.84E-12 | 6.90E-04 | 7.448 |
EPHA7 | Q15375 | Pkinase_Tyr | 1.53E-11 | 1.33E-04 | 7.345 |
ZAP70 | P43403 | Pkinase_Tyr | 1.20E-03 | 4.61E-12 | 7.129 |
PRKACA | P17612 | Pkinase | 2.93E-09 | 8.13E-06 | 6.811 |
KIT | P10721 | Pkinase_Tyr | 6.81E-10 | 4.21E-04 | 6.271 |
LCK | P06239 | Pkinase_Tyr | 4.20E-03 | 3.39E-10 | 5.923 |
MAP2K1 | Q02750 | Pkinase | 1.45E-04 | 1.26E-08 | 5.870 |
RET | P07949 | Pkinase_Tyr | 7.21E-04 | 1.82E-05 | 3.941 |
AXL | P30530 | Pkinase_Tyr | 6.76E-04 | 7.84E-05 | 3.638 |
CSNK1A1L | Q8N752 | Pkinase | 1.03E-04 | 2.01E-03 | 3.341 |
HCK | P08631 | Pkinase_Tyr | 5.29E-05 | 4.97E-03 | 3.290 |
FGFR2 | P21802 | Pkinase_Tyr | 5.20E-04 | 3.47E-03 | 2.872 |
AKT1 | P31749 | PH | <1.00E-14 | 2.12E-04 | 8.837 |
EGFR | P00533 | GF_recep_IV | <1.00E-14 | 1.68E-03 | 8.387 |
PAK2 | Q13177 | PBD | 2.15E-11 | 1.31E-03 | 6.775 |
PRKCB | P05771 | Pkinase_C | 3.68E-08 | 6.94E-05 | 5.797 |
EGFR | P00533 | Recep_L_domain | 6.07E-07 | 3.74E-04 | 4.822 |
EPHB2 | P29323 | EphA2_TM | 4.08E-03 | 6.38E-07 | 4.293 |
EPHA3 | P29320 | EphA2_TM | 5.75E-06 | 9.32E-04 | 4.136 |
TTN | Q8WZ42 | PPAK | 1.93E-04 | 4.29E-05 | 4.041 |
EPHB1 | P54762 | EphA2_TM | 3.75E-04 | 1.60E-04 | 3.612 |
BRDT | Q58F21 | Bromodomain | 3.72E-04 | 1.66E-03 | 3.104 |
TTN | Q8WZ42 | fn3 | 7.85E-04 | 9.89E-04 | 3.055 |
EPHA7 | Q15375 | EphA2_TM | 2.05E-03 | 5.65E-04 | 2.968 |
PRKCQ | Q04759 | Pkinase_C | 3.83E-03 | 1.08E-03 | 2.691 |
