Figure 10
From: Cystoid edema, neovascularization and inflammatory processes in the murine Norrin-deficient retina
Detection of neovascularization. At 3 months of age in two out of five eyes NV could be observed. (A,D) SLO angiography with FL, the position of the respective OCT scans (B–F) are depicted. V: ventral, d: dorsal, t: temporal, n: nasal, hs: horizontal scan, vs; vertical scan. In (B) OCT scan (left) with the corresponding retinal cryosection stained with hematoxylin (right) is shown. The histomorphology at 18 months of age corroborated the results obtained by OCT imaging. NV could be detected infiltrating the sub-RPE space and the ONL. The photoreceptor inner segments attached to the ONL appear to be dragged upwards by the invading vessel (yellow arrow), also RPE migration along the invading vessel was observed (red arrows). The detachment of the photoreceptor layer from the RPE was most likely produced by the histological procedure. GCL: ganglion cell layer, IPL: inner plexiform layer, INL: inner nuclear layer, OPL: outer plexiform layer, ONL: outer nuclear layer, OLM: outer limiting membrane, I/OS: photoreceptor inner/outer segment border, RPE: retinal pigment epithelium, CH: choroid. Scale bar, 50 µm.
