Figure 2
From: Cystoid edema, neovascularization and inflammatory processes in the murine Norrin-deficient retina
Defects in the retinal vasculature in the Ndphy/− retina at 18 months of age. Cryosections were labelled with Lectin-TRITC (red) for detection of vascular structures and counterstained with DAPI (blue). (A–D) In representative sections of two Ndphy/− mice the superficial vasculature at the level of the GCL and large microangiopathies extending into the INL (B,C) were detected. Although a single vessel could be observed at the level of the INL (D) the Norrin deficient retina remained virtually avascular until 18 months of age. (E) In age matched WT animals all three vascular layers that extend deep into the neuroretina were present. GCL: ganglion cell layer, IPL: inner plexiform layer, INL: inner nuclear layer, ONL: outer nuclear layer. Scale bar, 50 µm.
