Figure 2
p52 over-expression results in increased tumor number, size, and progression. (A) Average tumor number per lung section and (B) average tumor area from WT and CCSP-p52 mice 6 months after urethane injection (3 sections/mouse; n = 13–14 mice/group; *p < 0.05 compared to WT mice.). (C) Number and (D) proportion of lung tumors classified as adenomas, minimally invasive adenocarcinomas (MIA), or adenocarcinomas (n = 13–14 mice/group; *Χ2 p < 0.0001 for comparing total number of advanced lesions [MIAs and adenocarcinomas] between CCSP-p52 and WT mice).
