Figure 4 | Scientific Reports

Figure 4

From: Alternative polyadenylation drives genome-to-phenome information detours in the AMPKα1 and AMPKα2 knockout mice

Figure 4

Characterization of DE-APSs between AMPKα1 KO and AMPKα2 KO mice. (A) car3 was used as an example to show that knockouts trigged use of different polyA sites for functional detours. A polyA site in intron 2 was lost in AMPKα1 KO mice while a polyA site in intron 1 (extended from exon 1) was up-regulated in AMPKα2 KO mice in comparison to WT animals. For both knockout cases, each had one site as reference without significant difference. The DESeq normalized count for each site is also presented. (B) DE-APS clusters were identified along each murine chromosome, which required at least 3 DE-APSs within a 5-Mb window.

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