Figure 1 | Scientific Reports

Figure 1

From: Overactive autophagy is a pathological mechanism underlying premature suture ossification in nonsyndromic craniosynostosis

Figure 1

Characterization of the fused and unfused cranial SMCs. (A) Cell surface antigen phenotyping of human calvarial SMCs. Flow cytometric analysis showing the surface expression of CD90, CD105, and CD73, indicative of a mesenchymal immunophenotype, on both fused and unfused SMCs. PE: PE-labeled negative multipotent mesenchymal stromal cell (MSC) cocktail; control: negative control group. (B) Expression of the mesenchymal markers CD90, CD105, and CD73, as well as expression of the osteogenic markers ALP and BSP, and the chondrogenic marker COL1-A1 in fused and unfused SMCs, as determined by qPCR. Data are expressed as the mean ± SD of three independent experiments.

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