Table 2 The Variables Related to Severe Deep White Matter Lesions.

From: Low Bilirubin Levels Indicate a High Risk of Cerebral Deep White Matter Lesions in Apparently Healthy Subjects

 

Univariate Logistic Analysis

Multivariate Logistic Analysis

Odds ratio (95% CI)

p value

Odds ratio (95% CI)

p value

Bilirubin Group

  High-Bilirubin Group

1.00

reference

1.00

reference

  Intermediate-Bilirubin Group

1.53 (1.02–2.29)

0.040

1.33 (0.85–2.07)

0.214

  Low-Bilirubin Group

1.80 (0.96–3.36)

0.065

2.36 (1.12–4.97)

0.024

  

p for trend  = 0.026

 

P for trend  = 0.058

Age

1.12 (1.10–1.14)

<0.001

NA

NA

Male

1.08 (0.79–1.47)

0.644

NA

NA

Body Mass Index (1.0 increase)

1.03 (0.98–1.08)

0.230

NA

NA

Hemoglobin A1c (1% absolute increase)

1.39 (1.15–1.67)

0.001

NA

NA

Systolic Blood Pressure (10 mmHg increase)

1.22 (1.13–1.32)

<0.001

NA

NA

Smoke (vs never smoker)

  past smoker

1.44 (1.04–2.00)

0.027

NA

NA

  current smoker

0.95 (0.59–1.52)

0.822

NA

NA

Alcohol (vs none)

  1–5 days a week

0.50 (0.35–0.72)

<0.001

NA

NA

  ≥5 days a week

0.68 (0.47–1.00)

0.048

NA

NA

Log-transformed White Blood Cell Count

1.51 (0.88–2.61)

0.135

NA

NA

Hemoglobin

0.97 (0.86–1.09)

0.587

NA

NA

High-Density Lipoprotein Cholesterol

1.00 (1.00–1.01)

0.730

NA

NA

Low-Density Lipoprotein Cholesterol

1.00 (1.00–1.01)

0.835

NA

NA

Albumin

0.89 (0.50–1.59)

0.697

NA

NA

Uric Acid

1.09 (0.97–1.22)

0.135

NA

NA

  1. Multivariate logistic analysis was adjusted for age, gender, body mass index, hemoglobin A1c, systolic blood pressure, smoking, alcohol consumption, log-transformed white blood cell count, hemoglobin, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, albumin, and uric acid.
  2. NA: Not Applicable.