Figure 3 | Scientific Reports

Figure 3

From: In Vitro and In Vivo Characterization of PCC0104005, a Novel Modulator of Serotonin-Dopamine Activity, as an Atypical Antipsychotic Drug

Figure 3

The effect of PCC0104005 on 5-HTP induced head twitches within 30 minutes. Rats were administered an oral dose of vehicle alone (0.5% methylcellulose, 1 ml/kg), PCC0104005 (1.5, 3.0, or 6.0 mg/kg), aripiprazole (Ari, 1.5 mg/kg) or risperidone (Ris, 0.2 mg/kg) was orally administered 1 hour before the experiment. Twenty minutes later, 0.9% saline or 5-HTP (320 mg/kg) was intraperitoneally injected, and the total number of head twitches was recorded during a period of 40–70 min after intraperitoneal injection. Results are presented as mean ± S.E.M. (n = 8). *P < 0.05, **P < 0.01 model group vs. the control group, #P < 0.05, ##P < 0.01 drug delivery groups vs. the model group.

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