Table 1 Receptor binding affinity of PCC0104005, as measured by radioligand displacement assays: comparison with antipsychotic medications.

From: In Vitro and In Vivo Characterization of PCC0104005, a Novel Modulator of Serotonin-Dopamine Activity, as an Atypical Antipsychotic Drug

Drugs

D2

D3

D4

5-HT1A

5-HT2A

5-HT2B

5-HT2C

5-HT6

5-HT7

α1A

α1B

H1

PCC0104005a

0.11

0.14

24

—

5.1

0.34

36

85

5

8.3

3.2

1.1

Aripiprazoleb

0.34

0.8

44

1.7

3.4

0.4

15

—

39

57

—

61

Risperidoneb

3.57

14.7

4.66

423

0.17

61.9

12

—

6.6

3

—

60

  1. aPCC0104005 affinities were determined as described in the “Materials and Methods” section.
  2. bBinding affinities for other compounds were derived from Wikipedia.
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