Figure 6 | Scientific Reports

Figure 6

From: High Basolateral Glucose Increases Sodium-Glucose Cotransporter 2 and Reduces Sirtuin-1 in Renal Tubules through Glucose Transporter-2 Detection

Figure 6

Immunohistochemical analysis of SIRT1 and SGLT2 expression in human renal biopsy specimens. (A) Representative photomicrographs of hematoxylin and eosin staining or immunostaining of SIRT1 and SGLT2 in renal needle-biopsy specimens of patients with diabetic nephropathy (DN) (DN-1 and -5, Table 1 for patient details). Scale bar, 50 nm. (B) The relationship between the intensity of immunostaining of SIRT1 and that of SGLT2 in the proximal tubular region in renal biopsy specimens from patients with DN, n = 11 subjects.

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