Figure 3

(a) One-dimensional electrostatic potential along the channel axis (white dotted line in panel (b)). The PMF for calcium is shown in red to aid orientation. (b) The two-dimensional electrostatic potential on a slice across RyR1. Dashed lines mark the outline of the channel to aid orientation. The locations of the two main PMF basis are marked by white crosses. The orange arrow indicates the direction of the calcium current. (c) Two red spheres were placed in the main PMF basins.