Figure 5
Hallmark heterogeneity signature analysis including and not including known cancer driver genes. In each row, the first circle plot show pathway enrichments at the population level when considering all the somatic variants (bars on the external circle) and when considering only variants not involving known high-confidence cancer driver genes (internal circle); the second circle plot compares the hallmark signatures resulting from SLAPenrich analysis including (bars on the external circle) or excluding (bars on the internal circle) the variants involving known high-confidence cancer genes. The bar plot shows a comparison, in terms of true-positive-rate (TPR) and positive-predictive-value (PPV), of the SLAPenriched pathways recovered in the filtered analysis vs. the complete analysis., The scatter plots on the right show a comparison between the resulting hallmark signatures.
