Table 2 Association between genetic risk scores (GRSs) and incident CHD among GERA minority subjects.

From: Weighted Multi-marker Genetic Risk Scores for Incident Coronary Heart Disease among Individuals of African, Latino and East-Asian Ancestry

 

GRS_12

GRS_51

African-Americans (n = 2,089)

Model 1a

1.17 (0.98–1.40)

1.11 (0.92–1.34)

Model 1b

1.16 (0.97–1.39)

1.09 (0.90–1.32)

Model 1c

1.17 (0.97–1.40)

1.09 (0.90–1.32)

Model 1d

1.20 (1.00–1.44)

1.14 (0.94–1.39)

Model 2a

   Tertile 2

1.33 (0.82–2.17)

1.14 (0.71–1.82)

   Tertile 3

1.81 (1.14–2.88)

1.42 (0.90–2.23)

Model 2b

   Tertile 2

1.33 (0.81–2.18)

1.06 (0.66–1.70)

  Tertile 3

1.78 (1.12–2.83)

1.34 (0.85–2.11)

Model 2c

  Tertile 2

1.33 (0.82–2.18)

1.06 (0.66–1.70)

  Tertile 3

1.78 (1.12–2.84)

1.34 (0.85–2.11)

Model 2d

Tertile 2

1.37 (0.82–2.29)

1.04 (0.63–1.71)

Tertile 3

1.86 (1.15–3.01)

1.49 (0.93–2.39)

 

Latinos (n = 4,349)

 

Model 1a

1.18 (1.01–1.37)

1.19 (1.02–1.39)

Model 1b

1.23 (1.05–1.43)

1.19 (1.02–1.39)

Model 1c

1.23 (1.05–1.44)

1.19 (1.02–1.38)

Model 1d

1.19 (1.01–1.40)

1.16 (0.99–1.36)

Model 2a

  Tertile 2

0.94 (0.62–1.41)

0.99 (0.65–1.48)

  Tertile 3

1.59 (1.09–2.31)

1.61 (1.12–2.34)

Model 2b

  Tertile 2

0.89 (0.59–1.34)

1.06 (0.70–1.60)

  Tertile 3

1.68 (1.15–2.45)

1.54 (1.06–2.24)

Model 2c

  Tertile 2

0.88 (0.58–1.33)

1.07 (0.71–1.62)

  Tertile 3

1.68 (1.15–2.45)

1.55 (1.07–2.25)

Model 2d

  Tertile 2

0.89 (0.58–1.37)

1.06 (0.69–1.62)

  Tertile 3

1.52 (1.02–2.25)

1.40 (0.95–2.06)

 

Asians (n = 4,804)

 

Model 1a

1.09 (0.93–1.29)

1.20 (1.02–1.41)

Model 1b

1.10 (0.93–1.30)

1.24 (1.05–1.46)

Model 1c

1.10 (0.94–1.30)

1.23 (1.04–1.46)

Model 1d

1.07 (0.91–1.28)

1.18 (0.99–1.40)

Model 2a

  Tertile 2

0.87 (0.57–1.33)

1.33 (0.87–2.03)

  Tertile 3

1.19 (0.79–1.79)

1.48 (0.98–2.25)

Model 2b

  Tertile 2

0.95 (0.62–1.46)

1.36 (0.89–2.09)

  Tertile 3

1.27 (0.84–1.92)

1.57 (1.04–2.39)

Model 2c

  Tertile 2

0.96 (0.63–1.47)

1.34 (0.88–2.06)

  Tertile 3

1.27 (0.84–1.92)

1.56 (1.02–2.36)

Model 2d

  Tertile 2

1.01 (0.65–1.57)

1.37 (0.88–2.12)

  Tertile 3

1.19 (0.77–1.83)

1.43 (0.93–2.22)

 

Fixed-effects Meta-analysis of All Minority Groups Combined (n = 11,242)

 

Model 1a

1.15 (1.04–1.26)

1.17 (1.06–1.29)

Model 1b

1.17 (1.06–1.28)

1.18 (1.07–1.30)

Model 1c

1.17 (1.06–1.28)

1.18 (1.07–1.30)

Model 1d

1.15 (1.04–1.27)

1.16 (1.05–1.28)

Model 2a

  Tertile 2

1.00 (0.78–1.29)

1.14 (0.89–1.47)

  Tertile 3

1.49 (1.18–1.89)

1.52 (1.20–1.92)

Model 2b

  Tertile 2

1.01 (0.78–1.30)

1.16 (0.90–1.49)

  Tertile 3

1.55 (1.22–1.97)

1.49 (1.18–1.89)

Model 2c

  Tertile 2

1.01 (0.79–1.31)

1.15 (0.90–1.48)

  Tertile 3

1.55 (1.22–1.97)

1.49 (1.18–1.89)

Model 2d

  Tertile 2

1.04 (0.80–1.36)

1.15 (0.89–1.50)

  Tertile 3

1.48 (1.15–1.90)

1.43 (1.12–1.84)

  1. CHD denotes coronary heart disease;
  2. Table entries are hazard ratios (95% CI);
  3. See Statistical Methods for explanation of Models 1a-1d and 2a-2d specifications.
Back to article page