Table 3 Model Calibration, Discriminative Capacity and Reclassification for Incident CHD among GERA minority subjects.
GRS_12 | GRS_51 | |
|---|---|---|
African-Americans (n = 2,089) | ||
Harrell C Statistic | ||
Model with FRS | 0.687 | 0.687 |
Model with FRS + GRS | 0.691 | 0.690 |
P value for difference | 0.57 | 0.45 |
Hosmer-Lemeshow Chi-Square | ||
Model with FRS | 9.7 (9); 0.38 | 7.8 (9); 0.55 |
Model with FRS + GRS | 11.3 (9); 0.26 | 6.2 (9); 0.72 |
P value for difference | ||
Integrated Discrimination Improvement (IDI) | ||
All Cohort | 0.18 (0.00–0.97) | 0.06 (−0.03–0.63) |
Intermediate Risk Subset | 0.31 (−0.07–1.53) | 0.18 (−0.09–1.68) |
Category-based Net Reclassification Index (NRI) in the Full Cohort | ||
Subjects with CHD events | 0.11 (0.00–0.22) | 0.02 (−0.05–0.10) |
Subjects without CHD events | −0.01 (−0.02–0.01) | −0.01 (−0.02–0.00) |
All subjects | 0.10 (−0.01–0.21) | 0.02 (−0.06–0.09) |
Bias-corrected Category-based Net Reclassification Index (NRI) in the Intermediate Risk Subset | ||
Subjects with CHD events | 0.15 (0.02–0.28) | 0.03 (−0.07–0.12) |
Subjects without CHD events | −0.02 (−0.07–0.03) | −0.02 (−0.06–0.01) |
All subjects | 0.13 (−0.01–0.27) | 0.00 (−0.09–0.10) |
Latinos (n = 4,349) | ||
Harrell C Statistic | ||
Model with FRS | 0.714 | 0.714 |
Model with FRS + GRS | 0.717 | 0.715 |
P value for difference | 0.54 | 0.86 |
Hosmer-Lemeshow Chi-Square | ||
Model with FRS | 6.1 (9); 0.73 | 6.1 (9); 0.73 |
Model with FRS + GRS | 8.6 (9); 0.48 | 7.2 (9); 0.62 |
Integrated Discrimination Improvement (IDI) | ||
All Cohort | 0.16 (0.01–0.69) | 0.14 (−0.01–0.65) |
Intermediate Risk Subset | 0.39 (−0.03–2.22) | 1.31 (0.14–5.01) |
Category-based Net Reclassification Index (NRI) in the Full Cohort | ||
Subjects with CHD events | 0.07 (−0.01–0.16) | 0.06 (−0.03–0.15) |
Subjects without CHD events | 0.00 (−0.01–0.01) | −0.01 (−0.02–0.00) |
All subjects | 0.07 (−0.01–0.16) | 0.05 (−0.04–0.14) |
Bias-corrected Category-based Net Reclassification Index (NRI) in the Intermediate Risk Subset | ||
Subjects with CHD events | 0.12 (−0.04–0.29) | 0.09 (−0.06–0.23) |
Subjects without CHD events | −0.03 (−0.06–0.01) | −0.04 (−0.07 – −0.00) |
All subjects | 0.10 (−0.06–0.26) | 0.05 (−0.10–0.20) |
Asians (n = 4,804) | ||
Harrell’s C Statistic | ||
Model with FRS | 0.745 | 0.745 |
Model with FRS + GRS | 0.747 | 0.750 |
P value for difference | 0.25 | 0.11 |
Hosmer-Lemeshow Chi-Square | ||
Model with FRS | 4.4 (9); 0.88 | 4.4 (9); 0.89 |
Model with FRS + GRS | 6.2 (9); 0.72 | 8.6 (9); 0.47 |
Integrated Discrimination Improvement (IDI) | ||
All Cohort | −0.01 (−0.06–0.18) | −0.01 (−0.11–0.19) |
Intermediate Risk Subset | 0.04 (−0.14–0.88) | −0.01 (−0.07–0.69) |
Category-based Net Reclassification Index (NRI) in the Full Cohort | ||
Subjects with CHD events | 0.08 (0.02–0.13) | 0.06 (−0.02–0.13) |
Subjects without CHD events | 0.00 (−0.01–0.01) | 0.00 (−0.01–0.01) |
All subjects | 0.07 (0.02–0.13) | 0.06 (−0.02–0.13) |
Bias-corrected Category-based Net Reclassification Index (NRI) in the Intermediate Risk Subset | ||
Subjects with CHD events | 0.12 (0.02–0.21) | 0.09 (−0.02–0.19) |
Subjects without CHD events | 0.01 (−0.02–0.03) | 0.00 (−0.03–0.03) |
All subjects | 0.13 (0.03–0.22) | 0.09 (−0.02–0.20) |
All Minority Groups Combined (n = 11,242) | ||
Harrell C Statistic | ||
Model with FRS | 0.723 | 0.723 |
Model with FRS + GRS | 0.725 | 0.723 |
P value for difference | 0.25 | 0.76 |
Hosmer-Lemeshow Chi-Square | ||
Model with FRS | 16.0 (9); 0.07 | 16.0 (9); 0.07 |
Model with FRS + GRS | 7.8 (9); 0.56 | 9.6 (9); 0.38 |
Integrated Discrimination Improvement (IDI) | ||
All Cohort | 0.07 (0.00–0.25) | 0.01 (−0.01–0.13) |
Intermediate Risk Subset | 0.16 (−0.00–0.58) | 0.06 (−0.01–0.59) |
Category-based Net Reclassification Index (NRI) in the Full Cohort | ||
Subjects with CHD events | 0.07 (0.02–0.11) | 0.03 (−0.00–0.06) |
Subjects without CHD events | 0.00 (−0.01–0.00) | 0.00 (−0.00–0.00) |
All subjects | 0.06 (0.02–0.11) | 0.03 (−0.00–0.06) |
Bias-corrected Category-based Net Reclassification Index (NRI) in the Intermediate Risk Subset | ||
Subjects with CHD events | 0.10 (0.04–0.16) | 0.04 (−0.01–0.09) |
Subjects without CHD events | −0.01 (−0.03–0.01) | 0.00 (−0.01–0.01) |
All subjects | 0.09 (0.03–0.16) | 0.04 (−0.01–0.09) |
