Table 2 Association between retinal diameters and leukocyte telomere length, stratified by sex, age or BMI.

From: Retinal microcirculation and leukocyte telomere length in the general population

Outcome

Agec

Model

Men (n = 124)

Women (n = 129)

P-Interaction sex × age × LTL

Estimate (95% CI)

Estimate (95% CI)

CRAEa

33.5

Model1

−0.71 (−3.78, 2.35)

−1.39 (−4.64, 1.86)

0.037

 

57.6

Model1

−4.57 (−7.25, −1.89)

−0.07 (−2.95, 2.80)

 
 

33.5

Model2

−0.44 (−3.16, 2.29)

−1.14 (−3.97, 1.69)

0.018

 

57.6

Model2

−4.30 (−6.67, −1.93)

0.18 (−2.36, 2.72)

 

CRVEa

33.5

Model1

−1.10 (−5.24, 3.05)

0.51 (−4.01, 5.03)

0.62

 

57.6

Model1

−0.88 (−4.53, 2.78)

–0.92 (−4.84, 2.99)

 
 

33.5

Model3

−0.60 (−4.42, 3.22)

1.22 (−2.88, 5.32)

0.23

 

57.6

Model3

1.31 (−2.11, 4.73)

−0.61 (−4.19, 2.98)

 

AVRb

33.5

Model1

−0.001 (−0.015, 0.013)

−0.004 (−0.019, 0.010)

0.028

 

57.6

Model1

−0.020 (−0.032, –0.008)

0.002 (−0.012, 0.015)

 

Outcome

BMI c

Model

Estimate (95% CI)

Estimate (95% CI)

P -Interaction sex × BMI × LTL

CRAEa

23.8

Model1

−1.54 (−4.21, 1.14)

−0.73 (−3.62, 2.15)

0.010

 

29.9

Model1

−5.88 (−8.64, –3.11)

0.42 (−2.26, 3.09)

 
 

23.8

Model2

−1.36 (−3.73, 1.02)

−1.14 (−3.67, 1.38)

0.0030

 

29.9

Model2

−5.07 (−7.52, −2.61)

0.78 (−1.56, 3.13)

 

CRVEa

23.8

Model1

−0.49 (−4.10, 3.12)

1.15 (−2.84, 5.14)

0.74

 

29.9

Model1

−2.94 (−6.75, 0.87)

−0.34 (−4.04, 3.36)

 
 

23.8

Model3

0.38 (−2.96, 3.73)

1.94 (−1.69, 5.58)

0.49

 

29.9

Model3

−0.19 (−3.78, 3.40)

−0.47 (−3.83, 2.90)

 

AVRb

23.8

Model1

−0.006 (−0.018, 0.006)

−0.008 (−0.021, 0.005)

0.010

 

29.9

Model1

−0.019 (−0.032, −0.007)

0.004 (−0.008, 0.016)

 
  1. Abbreviations: BMI, body mass index; CI, confidence interval; LTL, leukocyte telomere length; CRAE, central retinal arteriolar equivalent; CRVE, central retinal venular equivalent; AVR, arteriole-to-venule ratio. Model 1 adjusted for age, sex, systolic blood pressure, smoking status, BMI as fixed effects and adjusted for participants nested within a family cluster as random effect. Model 2 adjusted according to Model 1 with additional adjustment for CRVE; Model 3 adjusted according to Model 1 with additional adjustment for CRAE; aEstimates presented as difference in arteriolar or venular diameter (μm) for a 20% shorter LTL. bEstimates presented as difference in arteriole-to-venule ratio for a 20% shorter LTL; cage in years and BMI in kg/m2 provided for the 25th and 75th percentile. Significance for estimates: P ≤ 0.01, P < 0.0001.