Figure 6
Significant positive correlation of the fitness calculated based on individual and pooled phenotyping. The different columns represent the different conditions: lineages grown in the media, sub-inhibitory drug concentrations or three different concentrations above the WT IC90. The three rows represent the three different drugs. Each plot displays relative fitness calculated from the competition experiment versus the relative fitness derived from individual growth measurments. The coefficient R2 and the p-value of a Pearson’s product-moment correlation are provided for each linear regression model (*P < 0.05, **P < 0.001). Clones adapted to amikacin (AMK), cefepime (FEP), doxycycline (DOX) and media are displayed in yellow, blue, purple and green, respectively. The intensity of the color increases with the resistance level towards the drug they were evolved to.
