Figure 6
From: FTY720 Decreases Tumorigenesis in Group 3 Medulloblastoma Patient-Derived Xenografts
FTY720 decreased medulloblastoma tumor growth in vivo. (A) D425 cells (2.5 × 106 cells in 25% Matrigel™) were injected into the right flank of 6-week-old, female, athymic nude mice. When tumors reached an average of 100 mm3, mice were randomized to receive either vehicle (N = 7) or FTY720 (10 mg/kg/day) (N = 8) for 5 weeks. Animals treated with FTY720 (closed circles) had significantly smaller tumors than those treated with vehicle alone (closed squares). (B) Mice were weighed at the beginning of the experiment and at the time of euthanasia. There was no significant difference in animal weights between those treated with vehicle and those treated with FTY720.
