Figure 2
Effect of chronic hypertension on blood vessel morphology. (A) Sample hypertensive aorta and ophthalmic arteries from a hypertensive and normotensive rat, with Gomori-Aldehyde Fuchsin staining. (B) Aorta and ophthalmic artery wall:lumen ratio. (C) Aorta and ophthalmic artery wall area. (D) Aorta and ophthalmic artery elastin:wall ratio. (E) Correlation between peak vasodilation at low BP and aorta wall:lumen ratio. The solid black line represents the Deming regression (Y = −243.4X + 90.8, rs = −0.6, p = 0.009). (F) Correlation between peak vasodilation at low BP and ophthalmic artery wall:lumen ratio. (Deming regression Y = −2.15X + 11.3, rs = −0.01, p = 0.7) (G) Correlation between peak vasodilation at low BP and blood pressure integral over 12 weeks. The solid black line represents the Deming regression (Y = −0.031X + 62.7, rs = −0.65, p = 0.003). (*Indicates p < 0.05, **Indicates p < 0.01, ***Indicates p < 0.001).
