Figure 4
Effect of circumlimbal suture on retinal function in normotensive and hypertensive rats. (A,B) Group average ERG waveforms at baseline and week 12 in sutured eyes in normotensive (blue trace) and hypertensive (red trace) animals. The dashedblack lines represent the group average waveform in the unsutured control eye in each blood pressure group. Inner retinal responses are shown for a −5.31 logcdsm−2 flash. Outer retinal responses are shown for a 2.07 log cdsm−2 flash. (C) Change in retinal function (mean ± SEM, n = 8) relative to control eyes in normotensive animals. (D) Change in retinal function (mean ± SEM, n = 8) relative to control eyes in hypertensive animals. (E) Difference between ganglion cell and bipolar cell deficits (pSTR% − Vmax%) in hypertensive and normotensive animals. The shaded region indicates the 95% confidence interval derived from all animals at baseline. *Indicates p < 0.05, ***Indicates p < 0.001 for post-hoc comparisons of change in RmP3 versus STR, and Vmax versus STR amplitudes at each timepoint.
