Figure 4
From: Evaluation of WISP1 as a candidate gene for bone mineral density in the Old Order Amish
UCSC bioinformatics view of the WISP1 region (chr8:134214753–134241422, GRCh37/hg19). The light green, long vertical line indicates the position of SNPs. (A) The Base Position feature; (B) The WISP1 gene prediction using Ensembl gene prediction; (C) the chromatin state segmentation for the cell types using the imputed ChromHMM (Hidden Markov Model), orange: active enhancer, yellow: weak enhancer or enhancer acetylation, PaleTurquoise: Het (Heterochromatin), Silver: ReprPC (Repressed PolyComb); (D) four histone markers modification map in two cell lines generated by Broad Institute using ChIP-Seq. (E) shows the density signal of DNaseI HS and (F) shows the peaks of DNaseI HS in the osteoblast from ENCODE/OpenChrom(Duke University). HMM (Hidden Markov Model), STRM.MRW.MSC and BMDMSC (Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells; M.CHON.MRW.DR.MSC and cfBMDMSC (Chondrocytes from Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells); BONE.OSTEO (primary osteoblast); DS (density signal); PK (peaks).
