Figure 1 | Scientific Reports

Figure 1

From: The psoriasis-protective TYK2 I684S variant impairs IL-12 stimulated pSTAT4 response in skin-homing CD4+ and CD8+ memory T-cells

Figure 1

TYK2 variants and haplotypes analyzed in this study. The figure shows the most parsimonious ancestry for the four most common TYK2 haplotypes (frequency > 0.5%). The TYK2 gene tree is rooted at the ancestral G-A-C haplotype with red “X”’s indicating the most parsimonious history of mutation events giving rise to the three independently associated psoriasis SNPs rs34536443 G > C, rs12720356 A > C, and rs2304256 C > A. The ancestral allele at each SNP was determined using the UCSC Genome Browser and in each case agreed with the major allele. The three SNPs are presented in chromosomal (p → q) order on the plus strand, which corresponds to C-terminal to N-terminal order in the TYK2 gene. The minor/protective allele frequency (MAF) and single marker odds ratio (OR) are shown for each SNP. Frequencies and odds ratios are also shown for each haplotype.

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