Figure 6 | Scientific Reports

Figure 6

From: Characterizing the role of atrial natriuretic peptide signaling in the development of embryonic ventricular conduction system

Figure 6

Quantification of ventricular conduction system development in neonate day 1 (ND1) ventricles of wild type (WT) and NPRA+/− mice using a Cx40egfp+ reporter approach. (A) In the left ventricles (LV) of Cx40egfp/+/NPRA+/+ ND1 pups, the left bundle branch (LBB) was continuous with an extensively arborized Purkinje fiber (PF) network. Note the typical honeycomb pattern of PFs (arrows) in the septal surface and left and ventricular free wall (LVW). (B) In the LV of Cx40egfp/+/NPRA+/− pups, PF network appeared to be sparse with fewer egfp positive PF fibers (arrows) within the septal surface and LVW. N = 8–10 NDl pups per genotype. (C) Quantification of EGFP green pixels in ND1 ventricles of WT and NPRA+/− mice. *P < 0.005, Student’s unpaired t-test.

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