Figure 2 | Scientific Reports

Figure 2

From: Lack of genetic support for shared aetiology of Coronary Artery Disease and Late-onset Alzheimer’s disease

Figure 2

Signal plots of the APOE locus for LOAD and CAD. (a) LocusZoom42 signal plot of the APOE locus from the IGAP cohort. The strongest signal detected was for rs6857. Peak variant for CAD (rs4420638) and the APOE ε2 (rs7412) and ε4 (rs429358) variants are included. (b) Signal plot of the APOE locus from the CARDIoGRAMplusC4D meta-analysis. The strongest association signal detected was for rs4420638. Peak variant for LOAD (rs6857) and the APOE ε2 (rs7412) and ε4 (rs429358) variants are included. LD structure in both plots is in reference to the APOE ε4 (rs429358) variant.

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