Table 1 Results of Mendelian randomization analysis for CAD on LOAD.

From: Lack of genetic support for shared aetiology of Coronary Artery Disease and Late-onset Alzheimer’s disease

Risk Phenotype

Variant count

OR for LOAD[95% CI]

p-value

Cochran’s Q

df

p-value

CAD (GWS)

52

1.07 [1.01–1.15]

0.027

1868.13

51

<2.2 × 10−308

CAD (GWS) (Excluding APOE)

51

0.94 [0.88–1.01]

0.072

53.22

50

0.351

CAD (GWS) Egger MR

52

1.09 [0.47–2.54]

0.846

1868.13

51

<2.2 × 10−308

CAD (FDR)

190

1.05 [1.01–1,10]

0.024

2059.25

189

<2.2 × 10−308

CAD (FDR) (Excluding APOE)

189

0.99 [0.94–1.03]

0.553

247.40

188

0.002

  1. Results of the analysis of summary statistics from CAD and LOAD. GWS is Genome Wide Significant (p ≥ 5 × 10−8); FDR is a false discovery rate of 5%. APOE refers to the rs4420638 variant within the APOE locus.
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