Figure 5 | Scientific Reports

Figure 5

From: Exosome markers associated with immune activation and oxidative stress in HIV patients on antiretroviral therapy

Figure 5

Notch4 is expressed in human dendritic cells. (a) Notch4 gene expression profiles from Affymetrix microarray profiling of human and mouse immune cell lineages from different individual human donors (left) or different pools of C57BL/6 (B6) mice (right) from the ImmGen Consortium Database (www.immgen.org). Bar plots (top panel) show absolute NOTCH4 mRNA expression in individual cell lineages in the indicated cell types. Heatmaps show mean-centered gene expression values (red bars denote enrichment above background). NOTCH4 mRNA is expressed in dendritic cells in both human and mouse, whereas expression in NK cells is detected only in humans. (b) Representative density plots from flow cytometric analysis show gating strategy and expression of Notch4 in plasmacytoid and myeloid dendritic cell subpopulations in PBMCs (one representative donor from a total of n = 3 healthy donors). HSC, Hematopoietic stem cells; GN, Neutrophils; MO, Monocytes; DC, Dendritic cells; B, B lymphocytes; NK, Natural killer cells; T, T lymphocytes.

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