Figure 3
From: Transcriptomic integration of D4R and MOR signaling in the rat caudate putamen
Pathways involved in the countereffect of PD. (A) Normalized Enrichment Scores and FDR values for the 6 KEGG pathways significantly enriched in the “M2h vs C2h” and “MPD2h vs M2h” comparisons in the opposite direction. (B) Scatterplot of the differences between the means in the “M2h vs C2h” and “MPD2h vs M2h” comparisons for all 19587 expressed genes. (C) Scatterplots of the difference between the means in the same two comparisons for the genes involved in the 6 enriched pathways. In all scatterplots, the blue line represents the “perfect countereffect” line (y = −x), that is, the line on which the genes would lie if the countereffect of the addition of PD would be perfect (for example \({\overline{x}}_{{\rm{M}}2{\rm{h}}}-{\overline{x}}_{{\rm{C}}2{\rm{h}}}=0.5\); \({\overline{x}}_{{\rm{MPD}}2{\rm{h}}}-{\overline{x}}_{{\rm{M}}2{\rm{h}}}=-\,0.5\)).
