Table 3 Top five most significantly enriched biological functions within each breed and the DE genes involved within each specific function.

From: Transcriptome analyses reveal reduced hepatic lipid synthesis and accumulation in more feed efficient beef cattle

 

Biological Function

No. of genes

Genes involved in the biological function

(Angus)1

Lipid metabolism

21

ELOVL5, GATM, HP, LPIN1, ADIPOR2, CSF2RB, SLC22A2, CCDC80, ZBTB16, ACSS2, EDNRA, CPT1B, RXRG, APOA4, UGT2B17, SCD, FKBP5, G0S2, MARCO, PLA2G2D, DLK1

2

Molecular transport

20

ADIPOR2, APOA4, CCDC80, CPT1B, CSF2RB, DLK1, EDNRA, ELOVL5, G0S2, GATM, HP, LPIN1, MARCO, PLA2G2D, RXRG, SCD, SLC22A2, TP53INP1, UGT2B17, ZBTB16

3

Small molecular biochemistry

23

ACSS2, ADIPOR2, APOA4, CCDC80, CPT1B, CSF2RB, DLK1, EDNRA, ELOVL5, FKBP5, G0S2, GATM, HP, LPIN1, LURAP1L, MARCO, PLA2G2D, RXRG, SCD, SLC22A2, TP53INP1, UGT2B17, ZBTB16

4

Carbohydrate metabolism

13

SCD, CCDC80, UGT2B17, LPIN1, CSF2RB, PLA2G2D, GNAZ, TP53INP1, EDNRA, GATM, ADIPOR2, ELOVL5, APOA4

5

Energy production

6

SCD, CCDC80, LPIN1, G0S2, ADIPOR2, CPT1B

(Charolais)1

Lipid metabolism

14

ABCC4, AKR1C1/AKR1C2, ANXA2, CES1, CYP2C19, DLK1, LPIN1, NR0B2, PDK4, SCD, SLC4A4, SPNS2, THEM4, TNC

2

Molecular transport

17

ABCC4, AKR1C1/AKR1C2, ANXA2, CES1, CXCL2, DLK1, LPIN1, NR0B2, PDK4, SCD, SIRPA, SLC13A2, SLC4A4, SLC7A5, SPNS2, TNC, TP53INP1

3

Small molecule biochemistry

21

ABCC4, AK4, AKR1C1/AKR1C2, ANXA2, CES1, CYP2C19, DLK1, GPX3, LPIN1, LURAP1L, MIOX, NR0B2, PDK4, SCD, SLC13A2, SLC4A4, SLC7A5, SPNS2, THEM4, TNC, TP53INP1

4

Energy production

6

AKR1C1/AKR1C2, CYP2C19, LPIN1, NR0B2, PDK4, SCD

5

Cellular development

15

ANXA2, CXCL2, DLK1, GNAZ, GPNMB, LAMB3, LPIN1, NR0B2, PDK4, RND1, SCD, SIRPA, SLC7A5, TNC, TP53INP1

(KC)1

Amino acid metabolism

22

AASS, ACMSD, ARG1, ASL, ERBB2, GCH1, GCLC, GHR, GLS2, GNMT, GOT1, HAL, IGF1, IGFBP2, OAT, RXRG, SDS, SLC16A10, SLC22A7, SLC25A15, SLC7A2, TAT

2

Small molecule biochemistry

64

AASS, ABCG8, ACACA, ACMSD, ADA, AK4, AKR1B10, APOA1, ARG1, ASL, ASPG, ATP2A2, BAG3, CDKN1A, CES1, CPT1B, CXCL10, CYCS, CYP1A1, CYP2B6, DUSP1, EDNRA, ELOVL2, ERBB2, ERBB3, FGF21,GATA4, GCH1, GCLC, GHR, GLS2, GNMT, GOT1, HAL, HMGCR, IGF1, IGFBP2, INSIG1, LPIN1, MFSD2A, MKNK1, NMNAT2, NPC1, NR0B2, OAS1, OAT, OGDH, P2RY2, PER1, PNP, PPARGC1A, RBP5, RHOJ, RXRG, SCD, SDS, SLC16A10, SLC22A7, SLC25A15, SLC7A2, SQLE, STS, TAT, ZBTB16

3

Cell death and survival

64

ACACA, ADA, APMAP, APOA1, ARG1, ATP2A2, BAG3, BTG2, CCND1, CDKN1A, CES1, CXCL2, CXCL10, CYCS, CYP2B6, DDIT4, DUSP1, EDNRA, ERBB2, ERBB3, FGF21, FKBP5, GADD45B, GATA4, GCH1, GCLC, GHR, GLS2, GNL3, GNMT, HEYL, HLA-B, HLA-F, HMGCR, IGF1, IGFBP2, INSIG1, IRAK3, ITGA7, KYAT1, LRIG1, MANF, MKNK1, MOB3B, NMNAT2, NPC1, NR0B2, OAS1, OGDH, PER1, PIGR, PNP, PPARGC1A, PRAP1, RHOJ, RRS1, SCD, SERPINA3, TOP1, TP53INP1, TRIB2, UHRF1, USP2, ZBTB16

4

Lipid metabolism

43

ABCG8, ACACA, ADA, AKR1B10, APOA1, ASPG, ATP2A2, BAG3, CDKN1A, CES1, CPT1B, CXCL10, CYCS, CYP1A1, CYP2B6, DUSP1, EDNRA, ELOVL2, ERBB2, FGF21, GATA4, GHR, GNMT, GOT1, HMGCR, IGF1, IGFBP2, INSIG1, LPIN1, MFSD2A, MKNK1, NPC1, NR0B2, OGDH, P2RY2, PER1, PPARGC1A, RBP5, RXRG, SCD, SQLE, STS, ZBTB16

5

Molecular transport

45

ABCG8, ACACA, ADA, APOA1, ARG1, ATP2A2, BAG3, CDKN1A, CES1, CPT1B, CXCL10, CXCL2, CYP1A1, DUSP1, EDNRA, ELOVL2, ERBB2, ERBB3, FGF21, GATA4, GHR, GNMT, HMGCR, HOOK1, IGF1, INSIG1, LPIN1, MFSD2A, NPC1, NR0B2, P2RY2, PER1, PIGR, PNP, PPARGC1A, RHOJ, RXRG, SCD, SLC16A10, SLC16A6, SLC22A7, SLC25A15, SLC38A7, SLC7A2, ZBTB16

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