Figure 1 | Scientific Reports

Figure 1

From: Perlecan, a heparan sulfate proteoglycan, regulates systemic metabolism with dynamic changes in adipose tissue and skeletal muscle

Figure 1

Hspg2−/−-Tg mice are resistant to obesity. (a,b) Body weight change of perinatal lethality-rescued perlecan knockout (Hspg2−/−-Tg, gray square) and control (WT-Tg, black circle) mice under (a) normal diet (ND) and (b) high fat diet (HFD) conditions. Body weight was monitored in the mice aged 6 to 16 weeks (mean ± S.D., n = 7). (c,d) Food consumption by WT-Tg and Hspg2−/−-Tg mice under (c) ND and (d) HFD conditions. The average consumption by 1 to 3 mice reared in the same animal cage represents food consumption per mouse (mean ± S.D., n = 4–6 cages). Data were analyzed by two-way ANOVA with Sidak’s multiple comparison. *p < 0.05, **p < 0.01, ****p < 0.0001.

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