Table 1 Minimal inhibitory concentrations (MICs) of five agents and fractional inhibitory concentration Indices (FICIs) of three combinations against three clinical MRSA isolatesa.

From: Synergistic combination of two antimicrobial agents closing each other’s mutant selection windows to prevent antimicrobial resistance

MRSA isolates

MIC (μg/mL)

FICI

RMb

DC

VM

OX

FF

RM/DC

VM/OX

VM/FF

01

0.13

0.25

1.00

1.00

64

0.26–0.50

0.75–1.25

1.00–1.25

02

0.13

0.13

2.00

2.00

32

0.28–0.38

1.00–1.50

1.25–1.50

03

32

0.13

0.50

2.00

32

0.53–0.75

1.25–1.50

1.00–1.25

  1. aThe data of FICI were published as an abstract of oral presentation at ISAAR&ICIC 201742.
  2. bRM: roxithromycin, DC: doxycycline, VM: vancomycin, FF: fosfomycin, OX: ofloxacin.
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