Figure 8
From: The Protease Activated Receptor2 Promotes Rab5a Mediated Generation of Pro-metastatic Microvesicles
Schematic Diagram Showing That Trypsin Mediated PAR2 Stimulation Promotes Pro-migratory And Pro-invasive MVs Generation via Rab5a Activation. The activation of PAR2 by trypsin triggers PI3K-dependent AKT phosphorylation at Serine 473. This induces the activation of Rab5a from inactive GDP-bound form to active GTP-bound state resulting in actin polymerization which is critical for MVs generation. Rab5a activation also leads to cell migration and invasion. These MVs have the potential to induce cell migration and invasion.
