Table 2 Top 20 Diseases and Biofunctions associated with changes in IGF1 network mRNA expression patterns (diseases and functions significant to network molecules).

From: Intrauterine smoke exposure deregulates lung function, pulmonary transcriptomes, and in particular insulin-like growth factor (IGF)-1 in a sex-specific manner

Categories

Diseases or Functions Annotation

p-Value

# Molecules

Organismal Survival

organismal death

3.64E-05

15

survival of organism

3.90E-05

11

Organismal Injury & Abnormalities

lymphocytic cancer

1.11E-05

9

non-Hodgkin’s disease

6.94E-05

8

biliary tract tumor

6.71E-05

4

biliary tract cancer

6.71E-05

3

Respiratory Disease

obstructive pulmonary disease

7.95E-06

5

atelectasis

2.89E-05

3

small cell lung cancer

6.32E-05

3

abnormal composition of pulmonary surfactant

2.60E-06

2

congenital pulmonary alveolar proteinosis

3.66E-06

2

community acquired pneumonia

1.06E-05

2

abnormal secretion of pulmonary surfactant

4.90E-05

2

primary atelectasis

9.67E-05

2

Cell Death & Survival

apoptosis of myeloma cell lines

5.45E-05

5

survival of hepatic stellate cells

2.87E-05

2

DNA Replication. Recombination & Repair

DNA damage

3.18E-05

5

Respiratory System Development & Function

abnormal morphology of type II pneumocytes

1.11E-06

3

Inflammatory Response

cytotoxic reaction of breast cancer cell lines

3.03E-05

2

Organ Development

growth of mammary duct

6.59E-05

2

  1. Some diseases and functions appear in more than one category. Only one category for each function is shown for simplicity. *The p-value of overlap was calculated by the Fisher’s Exact Test.
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