Figure 4
From: TDP-43 regulation of stress granule dynamics in neurodegenerative disease-relevant cell types
SG coalescence is mediated by TDP-43 in motor and cortical neurons. (A,D) Representative images of siRNA-microinjected motor neurons and siRNA transfected cortical neurons (both siTDP-43 #1) treated with SA and labelled for polyadenylated mRNA with oligo(dT). Arrowheads show SGs of interest. Scale bar, 10 µm. Number of SGs per cell and individual SG size in (B,C) motor neurons (n = 3, N = 10) and (E,F) cortical neurons (n = 4, N = 10) measured at the indicated time points post-SA treatment. Data is expressed as the mean ± SEM is shown; Student t test *p < 0.05, **p < 0.005, ns: not significant.
