Figure 6 | Scientific Reports

Figure 6

From: MiR-23a transcriptional activated by Runx2 increases metastatic potential of mouse hepatoma cell via directly targeting Mgat3

Figure 6The alternative text for this image may have been generated using AI.

Model for the mechanism by which miR-23a promotes tumor metastasis by changing N-glycan branching on the cell surface. In mouse HCC cells, high expression levels of the transcription factor Runx2 activate the transcription of the miR-23a∼27a∼24-2 cluster by binding to its promoter (around −277 bp to −157 bp). Then, increased miR-23a levels restrain the expression of the glycosyltransferase Mgat3, which catalyzes the branch formation of bisecting β1,4-GlcNAc. Finally, the decrease in bisecting structures of N-glycans on the cell surface plays a positive role in metastasis.

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