Table 3 Subgroup analysis of Her2 Ile 655 Val polymorphism and its association with breast cancer risk.
S.no | Model | Odds Ratio(OR) | 95% CI | p-value |
|---|---|---|---|---|
1 | Caucasian | 0.953 | 0.895–1.015 | 0.136 |
Overall allele Val vs. Ile | ||||
2 | Homozygous Val-Val vs. Ile-Ile | 1.000 | 0.850–1.177 | 0.997 |
3 | Heterozygous Ile-Val vs. Ile-Ile | 0.903 | 0.833–0.979 | 0.013 |
4 | Recessive Val-Val vs. Ile-Ile + Ile-Val | 1.046 | 0.892–1.228 | 0.580 |
5 | Dominant Val-Val + Ile-Val vs. Ile-Ile | 0.917 | 0.850–0.990 | 0.027 |
6 | American | 0.996 | 0.912–1.088 | 0.936 |
Overall allele Val vs. Ile | ||||
7 | HomozygousVal-Val vs. Ile-Ile | 0.895 | 0.707–1.133 | 0.357 |
8 | Heterozygous Ile-Val vs. Ile-Ile | 1.038 | 0.929–1.160 | 0.511 |
9 | Recessive Val-Val vs. Ile-Ile + Ile-Val | 0.892 | 0.707–1.125 | 0.334 |
10 | Dominant Val-Val + Ile-Val vs. Ile-Ile | 1.019 | 0.917–1.133 | 0.725 |
11 | Afro-American | 1.318 | 0.970–1.792 | 0.077 |
Overall allele Val vs. Ile | ||||
12 | Homozygous Ile-Val vs. Ile-Ile | 1.128 | 0.814–1.563 | 0.469 |
13 | Dominant Val-Val + Ile-Val vs. Ile-Ile | 1.228 | 0.891–1.693 | 0.210 |
13 | African | 1.558 | 0.761–3.192 | 0.225 |
Overall allele Val vs. Ile | ||||
14 | Homozygous Val-Val vs. Ile-Ile | 5.408 | 1.211–24.159 | 0.027* |
15 | Heterozygous Ile-Val vs. Ile-Ile | 1.369 | 0.460–4.078 | 0.573 |
16 | Recessive Val-Val vs. Ile-Ile + Ile-Val | 4.907 | 1.103–21.839 | 0.037* |
17 | Dominant Val-Val + Ile-Val vs. Ile-Ile | 1.505 | 0.588–3.858 | 0.394 |
18 | European | 1.128 | 0.958–1.328 | 0.149 |
Overall allele Val vs. Ile | ||||
19 | Homozygous Val-Val vs. Ile-Ile | 1.000 | 0.829–1.205 | 0.997 |
20 | Heterozygous Ile-Val vs. Ile-Ile | 1.042 | 0.949–1.143 | 0.390 |
21 | Recessive Val-Val vs. Ile-Ile + Ile-Val | 0.987 | 0.822–1.185 | 0.889 |
22 | Dominant Val-Val + Ile-Val vs. Ile-Ile | 1.137 | 0.941–1.374 | 0.184 |
23 | Asian | 1.163 | 1.011–1.338 | 0.035* |
Overall allele Val vs. Ile | ||||
24 | Homozygous Val-Val vs. Ile-Ile | 1.176 | 0.916–1.510 | 0.203 |
25 | Heterozygous Ile-Val vs. Ile-Ile | 1.064 | 0.976–1.160 | 0.158 |
26 | Recessive Val-Val vs. Ile-Ile + Ile-Val | 1.149 | 0.897–1.473 | 0.272 |
27 | Dominant Val-Val + Ile-Val vs. Ile-Ile | 1.177 | 1.012–1.370 | 0.034* |
