Figure 4
Effects of LC27, LC67, and PM on the expression of tight junction proteins (A), activation of NF-κB (B), iNOS and COX-2 (C), and expression of inflammatory cytokines (D) in mice with TNBS-induced colitis. TNBS, except in the normal control group, was intrarectally administered to mice and test agents [saline, LC5, LC27, LC67, LC68 (2 × 109 CFU/mouse), or sulfasalazine (SUL; 50 mg/kg)] were orally administered for 3 days. Cytokines were determined by ELISA. iNOS, COX-2, and NF-κB signaling molecules were determined by immunoblotting. All values are shown as the mean ± SD (n = 6). #p < 0.05 vs. normal control group. *p < 0.05 vs. group treated with TNBS alone.
