Table 2 Effect of Bu Yi Yao enzyme activity for proinflammatory chemical synthesis or inflammatory cytokine or hormone signaling pathways.

From: Majority of Chinese Medicine Herb Category “Qing Re Yao” Have Multiple Mechanisms of Anti-inflammatory Activity

Item No

TNF-α

IL-6

INF-γ

Dexa

COX2

iNOS

Item No

TNF-α

IL-6

INF-γ

Dexa

COX2

iNOS

55

79

56

80

57

81

58

82

59

83

60

84

61

85

62

86

63

87

64

88

65

89

66

90

67

91

68

92

69

93

70

94

71

95

72

96

73

97

74

98

75

99

76

100

77

101

78

       
  1. TNF-α: TNFα-NFκB luciferase reporter; IL-6: IL-6-STAT3 luciferase reporter; INF-γ: INFγ-GAS luciferase reporter; Dexa: Dexamethasone-GRE luciferase reporter; COX2: COX2 enzyme activity; iNOS: iNOS enzyme activity. ↓: inhibition ≥ 50%; : stimulation ≥ 3 folds; —: no impact w/o β-glucuronidase treatment at concentration ≤ 750 µg/ml in the inflammatory cytokine or glucocorticoid signaling pathway and at concentration ≤ 4 mg/ml in COX2, iNOS enzyme activity assay.